Can hypermobility cause fatigue?

Yes, and fatigue is one of the most frequently underrecognised features of symptomatic hypermobility. It arises because muscles must work continuously to compensate for inadequate ligamentous support, and may be compounded by autonomic dysfunction, disrupted sleep, and the wider systemic effects of connective tissue differences. If fatigue is significant, it’s worth discussing specifically with your consultant as it may indicate a need for a more comprehensive approach.