Hypogonadism
Hypogonadism is when your sex hormones are low – testosterone in men and oestrogen in women. It can cause symptoms including low sex drive, increased body fat and mood changes.
What is hypogonadism?
Hypogonadism is a condition where the sexual glands, called gonads – testes in men and the ovaries in women – produce little or no hormones. That means low or no testosterone in men and oestrogen in women. You may be born with hypogonadism, or it can develop later in life after an injury or infection.
There are 2 types of hypogonadism:
Primary hypogonadism is when your testes or ovaries don’t work normally, so don’t produce enough testosterone or oestrogen.
Secondary hypogonadism is when the pituitary gland in your brain doesn’t produce the hormones that stimulate the testes or ovaries to function as they should.
At Welbeck, our consultants diagnose and treat patients with hypogonadism in our state-of-the-art Endocrinology centre.
More information
Many people with hypogonadism may not realise they have the condition. It can often be misdiagnosed as the symptoms it causes can also be associated with other conditions.
Symptoms of hypogonadism in men include:
reduced sex drive and/or erectile dysfunction
loss of armpit or pubic hair
shrinking testicles
hot flushes
low or zero sperm count
low mood or depression, reduced concentration, poor memory
increased body fat and breast tissue
decrease in endurance, strength and muscle mass
Symptoms of hypogonadism in women can be misdiagnosed as PMS pr peri/menopause:
tender breasts
dry skin
vaginal dryness or atrophy
weak or brittle bones (osteoporosis)
weight gain, especially in the belly
difficulty concentrating, fatigue and trouble sleeping
mood changes and irritability
hot flushes and night sweats
irregular or no periods (amenorrhea)
headaches before or during menstruation
low or no libido and painful intercourse (dyspareunia)
Primary hypogonadism happens when your testes or ovaries stop working normally. This can be caused by:
injury to the glands
medical treatments, such as chemotherapy or radiotherapy or surgery to remove the glands
exposure to certain drugs and chemicals when you’re in the womb
genetic conditions, including Klinefelter syndrome and Turner syndrome
complications of infection, including mumps and tuberculosis (TB)
certain autoimmune conditions
certain drugs such as opiates and anabolic steroids
Secondary hypogonadism happens when your pituitary gland doesn’t work as it should, and affects the testes or ovaries. This can be caused by:
pituitary gland disorders, such as a pituitary tumour
certain inflammatory diseases, such as sarcoidosis, histiocytosis and tuberculosis
HIV/AIDS
certain medications, including opiates
a genetic condition called Kallmann syndrome
Risk factors that might make you more likely to develop hypogonadism include:
ageing
obesity
low body fat or eating disorders
type 2 diabetes
Diagnosing hypogonadism usually involves an initial consultation where our endocrinology specialist will:
Take a history to get a full understanding of your family history, health status and risk factors.
Ask about your symptoms – what you’re experiencing, when they started, if anything affects how severe they are, and how your life is affected.
Do a physical examination.
Review any relevant scans and other previous investigations.
They may also recommend scans to see if there’s any damage or change to your pituitary gland, ovaries, or testes.
You can’t prevent hypogonadism, but you can reduce some of your risk factors by:
managing diabetes, eating disorders, autoimmune conditions, or problems using opiates or anabolic steroids
maintaining a healthy weight
For men and women, hypogonadism increases the risk of fragile bones, known as osteoporosis. This can increase your risk of bone fractures, especially in your wrists, ribs, hips, and spine.
For women, a lack of oestrogen may also increase the chances of cardiovascular problems.
Low levels of sex hormones can cause a range of symptoms and can also affect bone strength and psychological wellbeing. Our specialists will perform a detailed individual assessment and advise on the optimal replacement of these hormones to restore full health.
For men with hypogonadism, hormone therapy may be given via testosterone injection, gels, patches, pellets (implanted under the skin), or buccal tablets (sticky pills applied to the gums).
For women with hypogonadism, hormone replacement may be given in the form of oestrogen via patches, pills, gels, creams, sprays, and injections. You’ll also need progesterone if you have a womb, to keep the womb lining from growing too thick.
Our on-site pharmacy stocks products recommended by our consultants, so you can pick up your prescription immediately after your consultation.
At Welbeck, our endocrinologists are experts in their field and are dedicated to providing world-class care to every patient.
With access to colleagues across other specialties, our consultants are also able to refer within the Welbeck ecosystem if required to ensure you receive the treatment you need as quickly as possible, all under one roof.
All appointments, testing, treatment, and follow-up appointments take place within our state-of-the-art facilities, enabling us to deliver accurate diagnostics and advanced treatments.
Your health is important to us, so we strive to offer same-day appointments whenever possible.
Our consultants are recognised by the major health insurance companies. If you have private health insurance, your treatment at Welbeck can begin once you have obtained authorisation. We also provide care to self-paying patients. Learn more about the different payment options at Welbeck.
Get in touch today to book an appointment.
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Frequently asked questions
Primary hypogonadism affects around 2% of men. Around 11% of men have secondary hypogonadism, which is more common as you get older and have a greater chance of being overweight, having type 2 diabetes, or needing medicines or cancer treatments that can contribute to it.
In women, estimates are harder to find, and as post menopause is a natural state of hypogonadism, this changes the way it can be assessed because you could say all women after menopause have hypogonadism.
Fertility problems are one of the ways hypogonadism can come to be diagnosed. It can affect the chances of having children through various means – from a lack of erection to a low or absent sperm count in a man, and a lack of periods, which means a lack of ovulation, in a woman. If you’ve been trying to conceive for 12 months with no luck, seek help from a medical professional to get a thorough investigation.
It can be difficult to know when to seek help because symptoms such as a low sex drive, mood changes, and weight gain around the middle could be due to so many things. If these issues affect your daily life and relationships, then it’s time to seek help. Clearer changes to prompt a consultant check include things like absent or irregular periods in a woman, hot flushes (before the age of 40 in a woman in particular), or genital changes such as shrinking testicles or vaginal dryness. If you get these kinds of changes after an infection or treatment, or when you have type 2 diabetes, you should seek help.
Everyone is different, and some people don’t get many side effects, some do and they settle down after a few weeks, and others may get them and need some help to manage. This is why it’s important to have monitoring and check-ups with your consultant, as they can modify your doses or help you cope with side effects.
For men, potential side effects include:
spots, usually on the back or chest
prolonged painful erection
aggression
blood thickening
changes in liver function
For women, potential side effects include:
headaches
breast pain or tenderness
unexpected vaginal bleeding, or spotting
feeling sick (nausea)
mood changes, including low mood or depression


