Prostate Biopsy

There are 2 main types of prostate biopsy:

• transrectal ultrasound (TRUS)-guided biopsy – this uses ultrasound imaging to guide a needle through the rectum into the prostate 

• transperineal biopsy – this uses ultrasound imaging to guide a needle through the skin between the testicles and the anus (the perineum) into the prostate

At Welbeck, we use the transperineal biopsy method, which is associated with a lower risk of infection.

Before the procedure, you’ll be asked to change into a hospital gown. Your consultant will explain the process and ensure you’re comfortable.

The procedure typically involves:

1. Administration of a local anaesthetic, or a combination of local anaesthesia with sedation or general anaesthesia.

2. Insertion of a lubricated ultrasound probe into the rectum to visualise the prostate.

3. Guidance of a biopsy needle through the perineum into the prostate using ultrasound imaging.

4. Collection of tissue samples either systematically or from targeted areas identified on MRI.

5. Removal of the probe and needle once sampling is complete.

After the procedure, your samples will be analysed and a report prepared. Your consultant will discuss the findings with you and recommend any further steps.

Understanding your results

If cancer is detected

A positive biopsy result can be distressing. Our specialist team will support you and guide you through the next steps. Further investigations may include:

• PET scan

• bone scan

• CT scan

Your treatment plan will depend on the stage and severity of the cancer.

If results are benign

If no cancer is found but PSA levels remain elevated, your consultant may recommend ongoing monitoring with regular blood tests and/or scans.

A transperineal prostate biopsy is generally safe. While very low levels of radiation may be used during imaging, the benefits of accurate diagnosis outweigh any minimal risks.

Some temporary side effects may occur, including:

• pain or discomfort – usually mild and short-lived, affecting the rectal, perineal, or lower abdominal area

• mild bleeding – blood may appear in urine, stools, or semen for up to two weeks

• temporary erectile dysfunction – rare and typically resolves within two months

• difficulty urinating – due to temporary prostate swelling

Although uncommon, infection can occur. Seek medical advice if you experience:

• pain or burning during urination

• cloudy or strong-smelling urine

• increased urgency or frequency of urination

• lower abdominal or back pain

To prepare for your procedure, you may be advised to:

• provide a urine sample to check for infection

• stop certain medications (like blood thinners such as warfarin, aspirin, or ibuprofen) approximately 5 days beforehand

• use a cleansing enema if instructed

• take prescribed antibiotics to reduce the risk of infection

Preparation requirements may vary, and you’ll receive specific instructions in advance of your appointment.

Most patients can return home on the same day as the procedure. It’s recommended to:

• rest and limit physical activity for 1 to 2 days

• take prescribed antibiotics if required

• avoid anal intercourse for at least 2 weeks or until discomfort has resolved

• use pain relief such as paracetamol if needed

If symptoms persist or worsen, you should contact your consultant.

For pricing information, please contact our Men’s Health centre directly for local anaesthetic prostate biopsies, or the Surgery Centre for biopsies performed under sedation or general anaesthesia.

At Welbeck, our experienced men’s health specialists are committed to delivering exceptional, patient-centred care. Our integrated approach allows seamless referrals across specialties within our network, ensuring timely diagnosis and treatment.

All consultations, diagnostics, and follow-up care take place in our state-of-the-art facilities, enabling accurate diagnosis and access to advanced treatment options.

A referral from your GP or urologist is required to book a prostate biopsy. Self-referrals are not accepted.

To arrange a consultation with a specialist, please contact us directly. We aim to offer same-day appointments whenever possible.

We are recognised by major health insurance providers. Treatment can begin once authorisation is received. Self-paying options are also available.